[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"node-by-slug-\u002Fen\u002Fcase-studies\u002Fcustomised-artificial-skin-for-burns-victims-en":3,"related-content-view":367},["Reactive",4],{"entity":5,"errors":-1},{"__typename":6,"status":7,"metatag":8,"id":207,"path":208,"title":209,"translations":210,"sharedHeaderRefMedia":218,"sharedTeaserTitle":209,"sharedTeaserText":244,"sharedTeaserRefMedia":246,"logo":248,"sharedParagraphs":258,"sharedTaxrefIndustries":348,"sharedTaxrefExpertises":352,"sharedIntroText":365,"sharedCtaLink":220},"NodeProject",true,[9,14,18,22,26,31,35,39,43,47,51,55,59,63,67,70,74,77,80,82,85,88,92,96,100,104,108,112,116,120,124,128,132,136,140,143,146,149,152,155,158,161,164,167,171,175,178,182,186,190,194,197,201,205],{"tag":10,"attributes":11},"meta",{"name":12,"content":13},"title","Artificial Skin for Burns: Customised, fast & scalable",{"tag":10,"attributes":15},{"name":16,"content":17},"description","Cutiss' idea: customised artificial skin for burn victims. Zuhlke assisted in getting its product ready for market by implementing an automated process.",{"tag":10,"attributes":19},{"name":20,"content":21},"abstract","CUTISS and Zühlke co-develop automated bio-engineered skin graft, denovoSkin™, revolutionising burn and skin surgery treatments.",{"tag":10,"attributes":23},{"name":24,"content":25},"icbm","51.525772, 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Engineering AG",{"tag":10,"attributes":56},{"property":57,"content":58},"og:type","website",{"tag":10,"attributes":60},{"property":61,"content":62},"og:url","https:\u002F\u002Fwww.zuehlke.com\u002Fen\u002Fcase-studies\u002Fcustomised-artificial-skin-for-burns-victims",{"tag":10,"attributes":64},{"property":65,"content":66},"og:title","CUTISS: New hope for burn victims and skin surgery patients – Zühlke",{"tag":10,"attributes":68},{"property":69,"content":21},"og:description",{"tag":10,"attributes":71},{"property":72,"content":73},"og:image","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Fmax_1300x1300\u002Fpublic\u002Fimages\u002Fcutiss-denovoskin.jpg?itok=V2TPyFFL",{"tag":10,"attributes":75},{"property":72,"content":76},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fimages\u002Fzuhlke_innovation_social.jpg",{"tag":10,"attributes":78},{"property":79,"content":73},"og:image:url",{"tag":10,"attributes":81},{"property":79,"content":76},{"tag":10,"attributes":83},{"property":84,"content":73},"og:image:secure_url",{"tag":10,"attributes":86},{"property":84,"content":87},"https:\u002F\u002Fwww.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fimages\u002Fzuhlke_innovation_social.jpg",{"tag":10,"attributes":89},{"property":90,"content":91},"og:image:alt","image",{"tag":10,"attributes":93},{"property":94,"content":95},"og:updated_time","2025-12-26",{"tag":10,"attributes":97},{"property":98,"content":99},"place:location:longitude","7.438014",{"tag":10,"attributes":101},{"property":102,"content":103},"place:location:latitude","46.947944",{"tag":10,"attributes":105},{"property":106,"content":107},"og:street_address","80 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New hope for burn victims and skin surgery patients",[211,214],{"path":208,"langcode":212},{"id":213},"en",{"path":215,"langcode":216},"\u002Fde\u002Fcase-studies\u002Fpersonalisierte-kuenstliche-haut-fuer-verbrennungsopfer",{"id":217},"de",{"id":219,"sharedMediaLegend":220,"mediaImage":221,"name":243},"170149",null,{"url":222,"width":223,"height":224,"alt":225,"title":220,"size":226,"mime":227,"variations":220,"headerMinimalVariations":228},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fimages\u002Fcutiss-denovoskin.jpg",996,1324,"\"\"",125332,"image\u002Fjpeg",[229,234,235,239,242],{"name":230,"url":231,"width":232,"height":233},"FOCAL_POINT32_SMALL","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_3_2_small\u002Fpublic\u002Fimages\u002Fcutiss-denovoskin.jpg.webp?itok=fQyWdcS7",800,533,{"name":230,"url":231,"width":232,"height":233},{"name":236,"url":237,"width":223,"height":238},"FOCAL_POINT169_MEDIUM","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_16_9_medium\u002Fpublic\u002Fimages\u002Fcutiss-denovoskin.jpg.webp?itok=r67Si0SR",561,{"name":240,"url":241,"width":223,"height":238},"FOCAL_POINT169_LARGE","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_16_9_large\u002Fpublic\u002Fimages\u002Fcutiss-denovoskin.jpg.webp?itok=abWf152L",{"name":240,"url":241,"width":223,"height":238},"cutiss-denovoskin.jpg",{"processed":245},"\u003Cp>CUTISS and Zühlke co-develop automated bio-engineered skin graft, denovoSkin™, revolutionising burn and skin surgery treatments.\u003C\u002Fp>",{"id":219,"sharedMediaLegend":220,"mediaImage":247,"name":243},{"url":222,"width":223,"height":224,"alt":225,"title":220,"size":226,"mime":227,"variations":220},{"id":249,"sharedMediaLegend":220,"mediaImage":250,"name":257},"4242",{"url":251,"width":252,"height":253,"alt":254,"title":220,"size":255,"mime":256,"variations":220},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fimages\u002Fcutiss-logo_0.png",1284,376,"Cutiss_Logo",103025,"image\u002Fpng","cutiss-logo.png",[259,266,274,280,312,318,342],{"__typename":260,"id":261,"ctaLink":220,"pgSharedText":262,"pgSharedTitle":220,"pgSharedCtaLink":220},"ParagraphPgText","22938",{"value":263,"processed":264,"format":265},"\u003Cul>\r\n\t\u003Cli>The production of lab-grown skin in a fully-closed system based on single use disposables was a big milestone, proving that CUTISS’s vision can become reality.\u003C\u002Fli>\r\n\t\u003Cli>This closed system can increase safety for both operators and patients and optimise the manufacturing facility space and maintenance whilst reducing costs.\u003C\u002Fli>\r\n\t\u003Cli>CUTISS and Zühlke are continuing their collaboration to scale-up denovoSkin™’s manufacturing process. This should provide new hope for patients requiring large amount of skin.\u003C\u002Fli>\r\n\u003C\u002Ful>\r\n","\u003Cul>\n\t\u003Cli>The production of lab-grown skin in a fully-closed system based on single use disposables was a big milestone, proving that CUTISS’s vision can become reality.\u003C\u002Fli>\n\t\u003Cli>This closed system can increase safety for both operators and patients and optimise the manufacturing facility space and maintenance whilst reducing costs.\u003C\u002Fli>\n\t\u003Cli>CUTISS and Zühlke are continuing their collaboration to scale-up denovoSkin™’s manufacturing process. This should provide new hope for patients requiring large amount of skin.\u003C\u002Fli>\n\u003C\u002Ful>","full_html",{"__typename":267,"id":268,"title":220,"media":269,"text":272,"primaryImage":220,"pgSharedTitle":273},"ParagraphPgContentVideoHighlight","14993",{"id":270,"mediaOembedVideo":271},"1035","https:\u002F\u002Fwww.youtube.com\u002Fwatch?v=vxvooivQWoo&feature=emb_logo","Zühlke supports Cutiss on its way to market maturity.","Personalised artificial skin for burn victims",{"__typename":260,"id":275,"ctaLink":220,"pgSharedText":276,"pgSharedTitle":279,"pgSharedCtaLink":220},"707",{"value":277,"processed":278,"format":265},"\u003Cp>Today’s standard of care in skin surgery is split-thickness skin autografting. A thin layer of skin is harvested from a patient’s own donor site and applied on the wounds. Donor site shortage is an unmet need in large wounds and split-thickness skin autografting often results in permanent, highly debilitating scars.\u003C\u002Fp>\r\n\r\n\u003Cp>The Swiss Life sciences start-up, CUTISS, wanted to revolutionise skin surgery by using personalised, bio-engineered skin that could improve patient’s quality of life by reducing scarring. CUTISS developed a process in which a personalised bilayer skin graft can be bio-engineered in the laboratory in large quantity starting from a postage stamp-sized skin sample. CUTISS developed a first-in-class automated process that collects keratinocytes and fibroblasts, expands them, and then uses them to create a skin tissue graft.\u003C\u002Fp>\r\n\r\n\u003Cp>Currently, the biotechnological manufacturing process is carried out manually. Automating the process is a key step for the life sciences start-up. That’s why CUTISS and Zühlke started a collaboration in 2018.\u003C\u002Fp>\r\n","\u003Cp>Today’s standard of care in skin surgery is split-thickness skin autografting. A thin layer of skin is harvested from a patient’s own donor site and applied on the wounds. Donor site shortage is an unmet need in large wounds and split-thickness skin autografting often results in permanent, highly debilitating scars.\u003C\u002Fp>\n\n\u003Cp>The Swiss Life sciences start-up, CUTISS, wanted to revolutionise skin surgery by using personalised, bio-engineered skin that could improve patient’s quality of life by reducing scarring. CUTISS developed a process in which a personalised bilayer skin graft can be bio-engineered in the laboratory in large quantity starting from a postage stamp-sized skin sample. CUTISS developed a first-in-class automated process that collects keratinocytes and fibroblasts, expands them, and then uses them to create a skin tissue graft.\u003C\u002Fp>\n\n\u003Cp>Currently, the biotechnological manufacturing process is carried out manually. Automating the process is a key step for the life sciences start-up. That’s why CUTISS and Zühlke started a collaboration in 2018.\u003C\u002Fp>","Automation – a major challenge",{"__typename":281,"id":282,"eyebrow":220,"pgQuoteRefQuote":283,"hideImage":220,"hideFunctionAndCompany":220,"bigQuote":220},"ParagraphPgQuote","1326",[284],{"status":7,"id":285,"promote":286,"quotePersonDesc":287,"quotePersonName":288,"quoteText":289,"profileImage":290,"title":311},"674",false,"CEO","Daniela Marino","To scale up, we needed a solid and local partner. The collaboration with Zühlke marked the kick-off of our pioneering automation programme.",{"id":291,"sharedMediaLegend":220,"mediaImage":292,"name":310},"170147",{"url":293,"width":294,"height":295,"alt":296,"title":220,"size":297,"mime":227,"variations":220,"quoteVariations":298},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fimages\u002Fdaniela-marino-cutiss_1.jpg",300,400,"portrait photo of Daniela Marino, CEO Cutiss",40606,[299,302,305,308,309],{"name":300,"url":301,"width":294,"height":294},"FOCAL_POINT11_EXTRA_SMALL","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_1_1_extra_small\u002Fpublic\u002Fimages\u002Fdaniela-marino-cutiss_1.jpg.webp?itok=Ackwgxhc",{"name":303,"url":304,"width":294,"height":294},"FOCAL_POINT11_SMALL","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_1_1_small\u002Fpublic\u002Fimages\u002Fdaniela-marino-cutiss_1.jpg.webp?itok=1hF3LcWC",{"name":306,"url":307,"width":294,"height":294},"FOCAL_POINT11_MEDIUM","https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_1_1_medium\u002Fpublic\u002Fimages\u002Fdaniela-marino-cutiss_1.jpg.webp?itok=vhMss2uh",{"name":306,"url":307,"width":294,"height":294},{"name":306,"url":307,"width":294,"height":294},"daniela-marino-cutiss.jpg","Daniela Marino, Cutiss ",{"__typename":260,"id":313,"ctaLink":220,"pgSharedText":314,"pgSharedTitle":317,"pgSharedCtaLink":220},"709",{"value":315,"processed":316,"format":265},"\u003Cp>Using agile methods and working in interdisciplinary teams, we analysed a range of factors and worked with CUTISS to develop a concept for a complete automated production process.\u003C\u002Fp>\r\n\r\n\u003Cp>With CUTISS, we developed a functioning prototype for the first step of the manufacturing e.g. cell isolation. The prototype included a sterilised disposable set comprising tubing and bags. The proof of concept demonstrated that it is indeed possible to isolate single cells from a skin biopsy automatically and in a fully closed fashion – an important milestone for CUTISS.\u003C\u002Fp>\r\n\r\n\u003Cp>Following an extensive test phase, we started working on developing the next generation cell isolation system. The system also included a new disposable set with a smart sample loading aid for which CUTISS and Zühlke were awarded the \u003Ca href=\"https:\u002F\u002Fwww.swissplastics-expo.ch\u002Fde\u002Fc\u002Fdas-war-die-swiss-plastics-expo-2023.30097\" target=\"_blank\">Swiss Plastics Expo 2023\u003C\u002Fa> \u003Ca href=\"https:\u002F\u002Fwww.swissplastics-expo.ch\u002Fde\u002Faward\" target=\"_blank\">Award for Engineering\u003C\u002Fa>.\u003C\u002Fp>\r\n","\u003Cp>Using agile methods and working in interdisciplinary teams, we analysed a range of factors and worked with CUTISS to develop a concept for a complete automated production process.\u003C\u002Fp>\n\n\u003Cp>With CUTISS, we developed a functioning prototype for the first step of the manufacturing e.g. cell isolation. The prototype included a sterilised disposable set comprising tubing and bags. The proof of concept demonstrated that it is indeed possible to isolate single cells from a skin biopsy automatically and in a fully closed fashion – an important milestone for CUTISS.\u003C\u002Fp>\n\n\u003Cp>Following an extensive test phase, we started working on developing the next generation cell isolation system. The system also included a new disposable set with a smart sample loading aid for which CUTISS and Zühlke were awarded the \u003Ca href=\"https:\u002F\u002Fwww.swissplastics-expo.ch\u002Fde\u002Fc\u002Fdas-war-die-swiss-plastics-expo-2023.30097\" target=\"_blank\">Swiss Plastics Expo 2023\u003C\u002Fa> \u003Ca href=\"https:\u002F\u002Fwww.swissplastics-expo.ch\u002Fde\u002Faward\" target=\"_blank\">Award for Engineering\u003C\u002Fa>.\u003C\u002Fp>","The first PoC",{"__typename":281,"id":319,"eyebrow":220,"pgQuoteRefQuote":320,"hideImage":220,"hideFunctionAndCompany":220,"bigQuote":220},"25116",[321],{"status":7,"id":322,"promote":286,"quotePersonDesc":323,"quotePersonName":324,"quoteText":325,"profileImage":326,"title":324},"25912","CIO","Vincent Ronfard","The collaboration with Zühlke has provided us with the engineering expertise that CUTISS needed to pursue tissue therapy innovation.",{"id":327,"sharedMediaLegend":220,"mediaImage":328,"name":341},"170148",{"url":329,"width":294,"height":295,"alt":330,"title":220,"size":331,"mime":227,"variations":220,"quoteVariations":332},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fimages\u002Fvincent-ronfard-cutiss.jpg","portrait photo of Vincent Ronfard, CIO of Cutiss",32488,[333,335,337,339,340],{"name":300,"url":334,"width":294,"height":294},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_1_1_extra_small\u002Fpublic\u002Fimages\u002Fvincent-ronfard-cutiss.jpg.webp?itok=lXuLM4-z",{"name":303,"url":336,"width":294,"height":294},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_1_1_small\u002Fpublic\u002Fimages\u002Fvincent-ronfard-cutiss.jpg.webp?itok=byHfvMP6",{"name":306,"url":338,"width":294,"height":294},"https:\u002F\u002Fcms.zuehlke.com\u002Fsites\u002Fdefault\u002Ffiles\u002Fstyles\u002Ffocal_point_1_1_medium\u002Fpublic\u002Fimages\u002Fvincent-ronfard-cutiss.jpg.webp?itok=igRCl3xY",{"name":306,"url":338,"width":294,"height":294},{"name":306,"url":338,"width":294,"height":294},"vincent-ronfard-cutiss.jpg",{"__typename":260,"id":343,"ctaLink":220,"pgSharedText":344,"pgSharedTitle":347,"pgSharedCtaLink":220},"25112",{"value":345,"processed":346,"format":265},"\u003Cp>A key feature of lab-grown skin production automation is the fully closed system based on single use disposables. A closed system can increase safety for both patients and operators and optimise the manufacturing footprint and maintenance whilst reducing costs.\u003C\u002Fp>\r\n\r\n\u003Cp>Today, Zühlke and CUTISS are continuing their collaboration.\u003C\u002Fp>\r\n","\u003Cp>A key feature of lab-grown skin production automation is the fully closed system based on single use disposables. A closed system can increase safety for both patients and operators and optimise the manufacturing footprint and maintenance whilst reducing costs.\u003C\u002Fp>\n\n\u003Cp>Today, Zühlke and CUTISS are continuing their collaboration.\u003C\u002Fp>","Optimising the manufacturing space and reducing costs",[349],{"id":350,"name":351},"13","MedTech",[353,356,359,362],{"id":354,"name":355},"19","Digital strategy",{"id":357,"name":358},"945","Prototyping",{"id":360,"name":361},"20","Hardware engineering",{"id":363,"name":364},"608","Sustainability",{"processed":366},"\u003Cp>Extensive skin burns, injuries, or defects often mean poor quality of life for those affected. With an innovative bio-engineered, personalised skin graft, denovoSkin™, CUTISS AG - founded as a spin-off from the University of Zurich \u002F University Children’s Hospital - wanted to take skin surgery to the next level and revolutionise current treatment methods. 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